Dr. Peter DePergola’s Interview with UCLA Crux Publication

Aadi Ajmire

12/05/2024

This article includes the video recording and transcript of Dr. Peter DePergola’s Interview with Crux Publication.

Interview with Dr. Peter DePergola

Dr. Peter A. DePergola II is a distinguished figure in the field of neuroethics, holding multiple roles that bridge academia, clinical practice, and organizational leadership. He is the Chief Ethics Officer and Senior Director of Clinical and Organizational Ethics at Baystate Health. Dr. DePergola's academic journey includes a BA in Philosophy and Religious Studies from Elms College, an MTS in Ethics from Boston College, and a PhD in Healthcare Ethics from Duquesne University. He has completed advanced training in neuroethics at institutions such as the University of Pittsburgh School of Medicine, Tufts University School of Medicine, and Harvard Medical School. His research interests encompass the neuroethical implications of memory manipulation, narrative identity, and the metaphysics of hope. 

 

Interview Questions:

Question 1: Can you share one of the main pivotal moments in your academic career that led you to specialize in neuroethics?

 

Dr. DePergola shared that his interest in neuroscience began early, though he initially wasn’t sure how to approach the field—whether through a clinical or theoretical lens. His studies in philosophy introduced him to the philosophy of mind and consciousness, which helped him realize that his interests extended beyond traditional neuroscience. It wasn’t until he began studying ethics that he saw an opportunity to merge these fields, exploring how ethical considerations shape our understanding of the brain and decision-making.

 

During his doctoral studies in healthcare ethics, he found neuroethics to be the perfect bridge between these disciplines. He became fascinated by the two-way relationship between neuroscience and ethics—how neuroscience informs ethical decision-making and how ethics should guide the development of emerging neurotechnologies. This realization set the foundation for his work in neuroethics, where he now addresses complex issues like deep brain stimulation, neuromodulation, and cognitive enhancement.

 


 

Question 2: What are some of the biggest ethical concerns in neurotechnology today?

 

According to Dr. DePergola, one of the most pressing ethical issues in neurotechnology is cognitive liberty—the right of individuals to control their own mental processes without undue influence. With advancements in brain-computer interfaces and neuromodulation, there is growing concern that such technologies could be used to manipulate thoughts, emotions, or behaviors in ways that undermine personal autonomy. Ensuring informed consent and protecting individuals from coercion will be critical as these technologies become more sophisticated.

 

Another major concern is privacy and security. Neural data, he explained, is deeply personal, and if it falls into the wrong hands, it could be misused in ways that threaten individual rights. He highlighted the need for strict regulations to prevent corporations or governments from exploiting this information. Additionally, he pointed to the issue of accessibility and fairness—ensuring that neurotechnologies do not widen the gap between those who can afford cognitive enhancements and those who cannot. Without careful ethical oversight, these advancements could create societal divisions rather than benefiting all.

 


 

Question 3: How do you see the role of neuroethics evolving in the next decade?

 

Dr. DePergola believes that neuroethics will only grow in importance as neurotechnology becomes more integrated into daily life. He envisions a future where interdisciplinary collaboration between ethicists, neuroscientists, policymakers, and engineers becomes the norm. By working together, these fields can ensure that ethical considerations are embedded into the design and application of new technologies rather than being addressed as an afterthought.

 

Additionally, he emphasized the growing need for public engagement in neuroethics. As these technologies become more widely available, the general public will need to be educated on their ethical implications. He suggested that neuroethicists should play a more active role in shaping public discourse, helping society navigate complex issues like cognitive enhancement, AI-driven brain augmentation, and the moral status of neuro-modified individuals. He concluded that neuroethics will not just be a specialized academic field but a crucial part of how we shape the future of neuroscience and technology.

 


 

Question 4: What ethical challenges do you foresee in the use of AI in neuroscience?

 

Dr. DePergola pointed out that the intersection of AI and neuroscience raises difficult ethical questions, particularly regarding decision-making and agency. AI-driven neurotechnologies, such as predictive models for diagnosing mental health conditions or machine-learning algorithms that assist in brain stimulation therapies, introduce concerns about human oversight. If AI systems become heavily involved in neurological treatments, we must carefully consider how much control they should have and ensure that their recommendations align with ethical principles.

 

Bias in AI models is another significant issue. He warned that if AI systems are trained on biased data, they may reinforce existing disparities in healthcare. This could lead to unequal treatment outcomes, where certain populations receive lower-quality care due to algorithmic errors or systemic biases. Transparency in AI development and strict regulatory oversight will be essential to address these concerns. He stressed that while AI has the potential to revolutionize neuroscience, it must be guided by ethical frameworks that prioritize fairness, accuracy, and patient well-being.

 


 

Question 5: What advice would you give to students interested in neuroethics?

 

Dr. DePergola encouraged students to embrace an interdisciplinary approach, as neuroethics requires knowledge from multiple fields, including neuroscience, philosophy, psychology, and law. He advised students not to limit themselves to just one perspective but instead to explore how different disciplines interact. This broader understanding, he said, is crucial for tackling the complex ethical issues that arise in neurotechnology.

 

He also emphasized the importance of staying engaged with real-world ethical dilemmas. Reading about neuroethics is valuable, but he suggested that students seek out hands-on experiences, such as research opportunities, ethics committees, or discussions with professionals in the field. He concluded by reminding students that neuroethics is not just about theoretical debates—it’s about shaping the future of neuroscience in a way that respects human dignity and advances societal well-being.

 


 

Question 6: How do you approach ethical decision-making in clinical neuroethics cases?

 

Dr. DePergola explained that ethical decision-making in clinical neuroethics requires a balance between theoretical frameworks and practical realities. He emphasized the importance of principlism—a method based on four core ethical principles: autonomy, beneficence, non-maleficence, and justice. In clinical cases, these principles serve as a foundation for assessing whether a particular neurotechnology or treatment aligns with ethical standards.

 

However, he acknowledged that ethical dilemmas are rarely clear-cut. Many cases require navigating conflicts between these principles, such as when a patient’s autonomy might clash with concerns about their well-being. In such situations, he relies on a process of ethical deliberation, which involves consulting with medical professionals, patients, families, and ethics committees. His approach also emphasizes the need for humility—acknowledging that ethical decisions are often complex and that the best course of action must be guided by compassion, transparency, and a commitment to doing what is right in each individual case.

 


 

Question 7: What role do you think policymakers should play in regulating neurotechnology?

 

Dr. DePergola argued that policymakers must take a proactive role in establishing ethical and legal safeguards for neurotechnology. He expressed concern that technological advancements often outpace regulation, leading to ethical gray areas where individuals may be vulnerable to exploitation or harm. To address this, he called for a policy framework that ensures responsible innovation while protecting fundamental human rights.

 

He highlighted the need for international collaboration in policy development, as neurotechnologies are not confined by borders. If different countries have drastically different regulations, it could create ethical loopholes where corporations or researchers seek out regions with the least oversight. He suggested that policymakers work closely with neuroethicists, scientists, and legal experts to craft regulations that are both flexible enough to accommodate new discoveries and strict enough to prevent misuse. He concluded by stressing that neurotechnology governance should prioritize public well-being over corporate or governmental interests.

 


 

Question 8: Do you believe there should be limits to neuroenhancement technologies?

 

Dr. DePergola acknowledged that neuroenhancement is one of the most ethically challenging areas in neuroethics. While some enhancements—such as deep brain stimulation for Parkinson’s disease—are therapeutic, others raise concerns about fairness, identity, and societal impact. He pointed out that if cognitive enhancement technologies become widely available, they could create a divide between those who can afford enhancements and those who cannot, leading to a form of neuro-inequality.

 

Another concern is the potential loss of authenticity in human experiences. He questioned whether enhancing intelligence or memory artificially could undermine the value of personal effort and growth. He also raised philosophical questions about personal identity—if someone alters their brain significantly through neuroenhancement, do they remain the same person? While he didn’t advocate for banning neuroenhancement entirely, he strongly supported the idea that ethical guidelines should dictate its responsible use, ensuring that enhancements do not compromise fairness, safety, or individual dignity.

 


 

Question 9: How do you see the relationship between ethics and emerging neurotechnologies evolving?

 

Dr. DePergola believes that ethics and neurotechnology will become increasingly intertwined, as ethical considerations will be crucial in determining how these technologies are developed and implemented. He argued that ethics should not be seen as an obstacle to progress but as an essential guide to ensuring that innovation benefits society as a whole. Without ethical oversight, neurotechnologies could easily be misused, leading to unintended consequences that could harm individuals or create societal divisions.

 

He also predicted that ethical discussions will need to become more nuanced as technologies evolve. For example, early discussions around brain-computer interfaces focused mainly on medical applications, but now they are expanding into consumer markets, raising new ethical challenges. As neurotechnologies become more powerful and widespread, he emphasized the need for ongoing dialogue between scientists, ethicists, policymakers, and the public. He concluded by stating that ethical reflection should be an integral part of technological progress, not something that happens after the fact.

 


 

Question 10: What excites you the most about the future of neuroethics?

 

Despite the challenges, Dr. DePergola expressed deep enthusiasm for the future of neuroethics. He is particularly excited about the growing awareness of neuroethical issues, both within the scientific community and among the general public. He sees this increased engagement as a sign that people are recognizing the importance of ethical considerations in shaping technological development.

 

He is also encouraged by the interdisciplinary nature of neuroethics, where experts from various fields—neuroscience, philosophy, law, medicine, and engineering—are coming together to address complex questions. He believes that this collaborative approach will lead to more thoughtful and responsible advancements in neurotechnology. Finally, he is hopeful that neuroethics will play a key role in ensuring that future innovations prioritize human dignity, fairness, and the well-being of all individuals, rather than simply maximizing technological capabilities.